Market Report Source

Overview

A microarray is an arrangement of miniaturized test sites or “spots” on a surface. Each spot is usually no more than 250 micrometers in diameter and contains biological molecules—usually DNA or protein—which act as probes for a test sample applied to the array. The surface may be a glass slide, a plastic plate with wells or a polymer bead. The microarray format allows many tests or experiments to be performed simultaneously, in parallel, leading to the generation of huge amounts of biological information for the application of only a tiny amount of sample. Microarrays are often also known as “biochips”. The purpose of this TriMark Publications report is to describe the specific segment of the microarray market aimed at analysis of proteins and DNA. Protein microarray applications include: 1) expression profiling; 2) serum-based diagnostics; 3) protein-protein binding assays; 4 drug-target binding; and 5) receptor epitope binding. It examines the market for DNA and protein array testing equipment and supplies using screening reagents and instruments for analysis of individual components in blood, serum or plasma. It defines the dollar volume of sales, both worldwide and in the U.S., and analyzes the factors that influence the size and the growth of the market segments. Also examined are the subsections of each market segment, including the research labs, hospital labs, and commercial laboratories. Additionally, the numbers of institutions using this type of testing and the factors that influence purchases are discussed. The report surveys almost all of the companies known to be marketing, manufacturing or developing instruments and reagents for the protein array market in the U.S. Each company is discussed in depth with a section on its history, product line, business and marketing analysis, and a subjective commentary of the company’s market position. The five main objectives of this analysis are:

· Identifying viable technology drivers through a comprehensive look at platform technologies for DNA and protein arrays, including, probe-based nucleic acid assays, microarrays and sequencing.

· Obtaining a complete understanding of the chief DNA and protein array tests from their basic principles to their applications.

· Discovering feasible market opportunities by identifying high-growth applications in different analytical diagnostic areas, focusing on the biggest and expanding markets.

· Focusing on global industry development through an in-depth analysis of the major world markets for DNA and protein array technology, including growth forecasts.

· Present market figures regarding the current value of the microarray market, projections and growth rates. The source of this information is the most current data derived from the global diagnostic industry.

By purchasing this report, you will have:

· An understanding of the most exciting microarray market segments, current and future.

· The latest information on leading products and research and development (R&D) initiatives.

· Familiarity with recent developments and their effects on selected markets.

· Knowledge of the microarray market as an area of growth, research and investment.

Key questions answered in this report:

· How can microarray tools and technologies facilitate drug discovery, design and development?

· What are the main types of array technologies that are currently available?

· Who are the current key players in this marketplace?

· Which microarray market areas have the greatest potential for growth?

· What is the current state of the microarray market?

· Which biotechnology and pharmaceutical companies are investing in microarray solutions?

· What are the main microarray business strategies adopted by leading companies?

· What are the benefits of microarray technology platforms?

This report contains:

· Detailed analysis of recent trends in the microarray marketplace.

· In-depth profiles of 16 leading companies with microarray tools and technologies.

· A five-year forecast for the microarray market in the biotechnology and pharmaceutical industries.

· Views and principles on the microarray industry from leading industry experts.

· Analysis of potential microarray applications in the life science sector.

· Market predictions and trends analysis concerning U.S. expenditure on array solutions.

· Projections for future applications of microarrays in drug discovery, from the industry’s R&D perspective.

· Analysis of commercial microarray business strategies.

· The latest news and developments in the microarray marketplace.

· A comprehensive overview and insight into microarray business strategies.

Table of Contents

1. Overview
1.1 Statement of Report
1.2 About This Report
1.3 Scope of the Report
1.4 Objectives
1.5 Methodology
1.6 Executive Summary

2. Overview of Microarrays
2.1 History of Microarrays
2.2 Genomics and Proteomics
2.2.1 Genetic Variability and Disease
2.3 General Theory of Microarrays
2.4 DNA Microarrays
2.5 Protein Microarrays
2.6 Tissue Microarrays

3. DNA Microarrays
3.1 Advantages and Drivers
3.2 Limitations and Barriers to Commercialization
3.3 DNA Microarray Technology Platforms
3.3.1 Reasons Why Researchers Utilize DNA Microarrays
3.3.2 Factors for Difficulties Applying DNA Microarrays Technology
3.4 Key Attributes of DNA Microarray Software
3.5 Applications
3.6 Future Directions for DNA Microarray Technology
3.6.1 High-Throughput Array Technology
3.6.2 Emerging Microarray Trends
3.6.3 Emerging Microarray Applications
3.6.4 Key Points for Developing Microarray Based Applications

4. Protein Microarrays
4.1 Critical Factors for Microarray Content
4.2 Key Findings on Use of Microarrays
4.3 Advantages and Drivers
4.4 Limitations and Barriers to Commercialization
4.5 Key Experimental Parameters of Protein Microarray Technology for Current and Future Users
4.6 Reasons Why Researchers Utilize Protein Microarrays
4.7 Factors for Adoption of Protein Microarrays Technology
4.8 Top Suppliers of Protein Microarray Slides and Products
4.9 Factors that Influence Sale Decisions
4.10 Future Innovations in Protein Microarray Technology

5. Current DNA Microarrays
5.1 Key Players
5.2 High Growth Applications
5.2.1 Microarray-Based Commercial Genotyping Activity
5.2.2 Location Analysis
5.3 Future Innovations in DNA Microarray Technology

6. Current Protein Microarrays
6.1 Protein Profiling Microarrays-Antibody Arrays
6.2 Protein Profiling Microarrays-Reverse Phase Microarrays
6.3 Multiplex Sandwich Microarrays-Planar
6.4 Multiplex Sandwich Immunoassays-Bead Based
6.5 Microarrays for Protein Function Studies
6.6 High Growth Applications
6.6.1 Cytokine Arrays
6.6.2 Whole Proteome Arrays
6.6.3 Microarray-Based Commercial Genotyping Activity
6.6.3.1 Microarray-Based Genotyping Applications
6.6.3.2 Microbial Applications
6.6.3.3 The Market for Microbial Genotyping Products
6.6.3.4 Comparative Genomic Hybridization
6.6.4 ChIP-on-Chip Analysis

7. Technology
7.1 Production of Microarrays
7.2 2-D Versus 3-D Technology
7.3 Substrates and Surface Chemistries
7.4 Detection Methods
7.5 Instruments
7.6 Data Management and Informatics in Gene Expression

8. Applications
8.1 DNA Microarrays in Gene Expression
8.2 DNA Microarrays in SNP Analysis
8.3 DNA Microarrays in Cancer
8.4 Protein Expression
8.4.1 Cytokine Applications
8.4.2 Protein Function
8.4.3 Protein-Protein Interactions
8.5 Target /Biomarker Discovery
8.6 Drug Discovery and Development (Gene and Protein Microarrays)
8.7 Clinical Diagnostics (Gene and Protein Microarrays)
8.8 RNA Microarrays
8.9 Oligo Microarrays
8.10 Yeast Microarrays
8.11 Antibody Arrays

9. The Commercial Opportunity for Microarrays
9.1 Market Drivers for Microarrays
9.2 Market Restraints for Microarrays
9.3 Key Players
9.4 Market Size, Strategic Trends and Competitive Landscape for Protein Arrays
9.5 Marketing and Distribution
9.6 Protein Arrays Market Analysis
9.7 Genes Associated with Major Diseases
9.8 Software and Data Analysis
9.8.1 Supplier of DNA Microarray Analysis Software
9.8.2 Satisfaction with Software Features
9.8.3 Satisfaction with Software
9.8.4 Supplier Factors in Software Purchase Decision
9.8.5 Suppliers’ Role in Improving Data Sharing for DNA Microarrays

10. Legal Aspects of Commercialization of Protein Arrays

11. Company Profiles

Appendix 1: Microarray Milestones

LIST OF FIGURES

Figure 5.1: Company Market Shares
Figure 8.1: Overall Market Size by Application, 2005
Figure 8.2: Source of Variation in Microarray Data

LIST OF TABLES

Table 3.1: Source of DNA Microarrays in Research Use
Table 3.2: Microarray Market Drivers
Table 3.3: Microarray Market Barriers
Table 3.4: Unit Pricing of DNA Microarrays, 2000-2010
Table 3.5: Steps in the Design and Implementation of a DNA Microarray Experiment
Table 3.6: The Main Features of Some Hybridization Microarray Formats Currently Available
Table 3.7: Microarray Applications
Table 3.8: List of DNA Array Manufacturers
Table 4.1: Critical Factors for Microarray Content
Table 4.2: Top Three Suppliers of Treated Protein Microarray Surfaces for Self-Printing
Table 4.3: Top Suppliers of Commercially Available Protein Microarrays
Table 4.4: Top Suppliers of Protein Microarray Readers
Table 5.1: Affymetrix Sales of Probe Arrays, 2000-2005
Table 5.2: Affymetrix Total Product Sales, 1999-2005
Table 5.3: Affymetrix Instrument Sales, 2000-2005
Table 6.1: Microarray Genetic Testing
Table 6.2: ChIP-on-Chip Microarray Market Size Projections, 2005-2011
Table 8.1: Applications of Biochips by Class
Table 8.2: Diagnostics Microarray Market Size Projections, 2005-2011
Table 8.3: HTS Microarray Market Size Projections, 2005-2011
Table 8.4: Pharmacogenomics Microarray Market Size Projections, 2005-2011
Table 8.5: Toxicology Screening Microarray Market Size Projections, 2005-2011
Table 8.6: Expression Profiling Microarray Market Size Projections, 2005-2011
Table 9.1: Market Share of Microarray Products, 2004
Table 9.2: Affymetrix Product Sales
Table 9.3: Agilent’s Net Revenue by Business Segment, 2002, 2003 and 2004
Table 9.4: Leading Microarray Companies
Table 9.5: Worldwide Microarray Market Size, 2004-2011
Table 9.6: Microarray Market Share by Technology Type
Table 9.7: DNA Microarray U.S. Market Size, 2005-2011
Table 9.8: DNA Microarray Worldwide Market Size, 2002-2011
Table 9.9: Biochip Market by Usage, 2003 and 2007